L-a-dipeptides (dipeptides) ba a yi nazarin kusan kusan suna da sunadaran da amino acid ba.An gudanar da bincike na farko akan L-aspartyl-L-phenylalanine methylester (aspartame) da Ala-Gln (Lalanyl-L-glutamine) saboda ana amfani da su a cikin shahararrun samfuran kasuwanci.Baya ga wannan gaskiyar, wani dalili kuma da yawa dipeptides ba a yi nazari sosai ba shine saboda samar da dipeptide ba shi da ingantattun hanyoyin samarwa, kodayake an ba da rahoton hanyoyin sinadarai da yawa da chemoenzymatic.
Carnosine - misali na dipeptide
Har zuwa kwanan nan, an ƙirƙiri sababbin hanyoyin don haɓakar dipeptide wanda aka samar da dipeptides ta hanyoyin fermentative.Wasu nau'ikan dipeptides suna da iyakoki na physiological na musamman, wanda ke ba su damar hanzarta aikace-aikacen dipeptide a fannoni daban-daban na binciken kimiyya.L-a-dipeptides sun ƙunshi mafi ƙarancin ƙarancin peptide bond na amino acid guda biyu, amma duk da haka ba sa samuwa da farko saboda ƙayyadaddun matakai masu tsada na masana'antu.Dipeptides, duk da haka, suna da ayyuka masu ban sha'awa, kuma bayanan kimiyyar da ke kewaye da su yana karuwa.Wannan yana barin masu bincike da yawa tare da cajin haɓaka hanyoyin da suka fi dacewa da farashi na samar da dipeptide.Lokacin da aka ƙara nazarin wannan filin, ana tsammanin za mu iya ƙarin koyo game da yadda peptides ke da kima da gaske.
Dipeptides suna da ayyuka na asali guda biyu, waɗanda sune:
1. Samfurin amino acid
2. Dipeptide kanta
A matsayin tushen amino acid, dipeptides, tare da amino acid ɗin su sun ƙunshi nau'ikan sinadarai na physiochemical daban-daban, amma yawanci suna yin tasiri iri ɗaya.Wannan shi ne saboda dipeptides sun lalace zuwa cikin keɓaɓɓen amino acid a cikin rayayyun halittu, waɗanda ke da nau'ikan sinadarai na physicochemical daban-daban.Misali, L-glutamine (Gln) yana da zafi, yayin da Ala-Gin (L-alanyl-L-glutamine) ke jure zafi.
Haɗin sunadarai na dipeptides yana faruwa kamar haka:
1. Ana kiyaye duk ƙungiyoyin dipeptide masu aiki (ban da waɗanda ke da hannu wajen ƙirƙirar haɗin peptide na amino acid).
2. Amino acid mai kariya na ƙungiyar carboxyl kyauta yana kunna.
3. Amino acid da aka kunna yana amsawa tare da sauran amino acid mai kariya.
4. An cire ƙungiyoyin kariyar da ke cikin dipeptide.
Lokacin aikawa: Afrilu-19-2021
